China (Mainland)
Experienced Exporter of Beta-Methyl Vinyl Phosphate（MAP）used in Pharmaceutical Industry CAS NO.90776-59-3
- FOB Price: USD: 420.00-588.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
1(1-1000)Kilogram1(1000-2000)Kilogram
- Product Details
Keywords
- Beta-Methyl Vinyl Phosphate（MAP）
- (4R,5S,6S)-3-(Diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate
- 4-nitrobenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Quick Details
- ProName: Experienced Exporter of Beta-Methyl Vi...
- CasNo: 90776-59-3
- Molecular Formula: C29H27N2O10P
- Appearance: White or off-white powder
- Application: It's used in Pharmaceutical Intermedia...
- DeliveryTime: Delivery on schedule
- PackAge: 25kg/barrel or as buyer’s request
- Port: Shanghai, Tianjin, Qingdao，etc.
- ProductionCapacity: 80 Metric Ton/Month
- Purity: 99%
- Storage: Room temperature
- Transportation: By Sea, By Airport, By Express
- LimitNum: 1 Kilogram
Superiority
Best Service，High Quality and Reasonable Price
Xinxiang Juyuan Biological Technology Co., Ltd. is specialized in the manufacture, research and development of pharmaceutical intermediates and fine chemicals, such as Biapenem, and series intermediates of Penem.
The company is armed with top-notch technicians, advanced production equipments and testing instruments as well as perfect Q.C. system. Products are sold not only around China, but also to Europe and the US as well as the Asia-Pacific Region.
Details
Detailed Parameters
| Name | Beta-Methyl Vinyl Phosphate（MAP） |
| Synonyms | (4R,5S,6S)-3-(Diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate |
| (1R,5R,6S)-6-[(1R)-1-Hydroxyethyl]-2-[(diphenylphosphono)-oxy]-1-methylcarbapen-2-em-3-carboxylic acid 4-nitrobenzyl ester | |
| 4-nitrobenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | |
| CAS | 90776-59-3 |
| EINECS | 618-646-2 |
| Molecular Formula | C29H27N2O10P |
| Molecular Weight | 594.51 |
| InChI | InChI=1/C29H27N2O10P/c1-18-25-24(19(2)32)28(33)30(25)26(29(34)38-17-20-13-15-21(16-14-20)31(35)36)27(18)41-42(37,39-22-9-5-3-6-10-22)40-23-11-7-4-8-12-23/h3-16,18-19,24-25,32H,17H2,1-2H3/t18-,19-,24-,25-/m1/s1 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Melting Point | 126－130℃ |
| Boling Point | 722.4±60.0 °C(Predicted) |
| Flash Point | 390.671°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance/Color | White to Off-White Powder |
| pKa | 14.36±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.653 |
| Use | Meropenem intermediate. A 1β-methyl carbapenem derivative as antibacterial agent. |
| Packing | 20kg/barrel（Lined with a plastic bag, sealed with an aluminum foil bag, and with a paper cylinder outside） |
| Specific spin | [α]D20 =+45°～+55° |
| PSA | 167.23 |
| LogP | 2.13 |
Application
Beta-Methyl Vinyl Phosphate is a pharmaceutical intermediate that can be used to prepare tibipenem pivoxil. Tibipenem pivoxil, chemically known as (+) - (4R, 5S, 6S) - 6 - [(1R) - hydroxyethyl] - 4-methyl-7-oxo-3 [[1 - (2-thiazolin-2-yl) - 3-azacyclobutanyl] sulfur] - 1-azabicyclic [3.2.0] hept-2-en-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy) methyl ester, is a carbapenem antibiotic. After absorption in the intestinal tract, Tibipenem pivoxil is metabolized to Tibipenem, showing antibacterial activity.
Tibipenem has broad-spectrum antibacterial activity against gram-positive bacteria and gram-negative bacteria, including Staphylococcus, Streptococcus, Pneumococcus (including PRSP), and Moraxella catarrhalis (including β- Lactam producing bacteria), Haemophilus influenzae (including ampicillin resistant Haemophilus influenzae) have strong antibacterial activity. In particular, compared to previous oral antibiotics, tibpenem exhibits extremely strong antibacterial activity against pathogenic bacteria such as otitis media, paranasal sinusitis, and pneumonia in children, penicillin resistant pneumococci, and macrolide resistant pneumococci.
The mechanism of action of tibpenem is to inhibit the synthesis of bacterial cell walls, have high affinity for various bacterial penicillin binding proteins (PBPs), and play a bactericidal role.
Tibipenem has a higher affinity for PBP1A, 2X, or 2B of penicillin-resistant pneumococci than other oral antibiotics β- Lactam antibiotics.
Packaging & Transport
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Company Profile
Xinxiang Juyuan Biological Technology Co., Ltd. is specialized in the manufacture, research and development of pharmaceutical intermediates and fine chemicals, such as Biapenem, and series intermediates of Penem.
The factory covers an area of 10,000 square meters, with complete green and environmental protection facilities. We have professional equipment such as Penan intermediate integrated production line, inorganic production workshop, and product quality circuit monitoring network to track pre-sale and after-sale products. At present, while stabilizing the domestic market, products are sold not only around China, but also to Europe and the US as well as the Asia-Pacific Region, and we have established a high-quality strategic cooperation network.
The company is armed with top-notch technicians, advanced production equipments and testing instruments as well as perfect Q.C. system.
Juyuan people adhere to the corporate philosophy of "seeking development through technology and survival through quality", focusing on the chemical industry field; Serving domestic and foreign customers with the marketing concept of "mutual benefit, mutual benefit, and win-win". Permanently committed to the biotechnology aircraft carrier brand!
FAQ:
Q1:Will you supply samples for testing
A: Free samples for the quality evaluation for most products, but customers only need to undertake the shipping fee for delivery the samples to your door.
Q2:What's your MOQ
A: Our MOQ starts from 1kg.
Q3:Which kind of payment terms do you accept
A: Payment by LC, T/T, D/P, PayPal, , Small-amount payment
Q4:How about your delivery time
A: Generally, it will take 3 to 5 days after receiving your advance payment.
Q5. Are you manufacturer or trade company
We are a comprehensive technology enterprise that focuses on the production and research and development of intermediates and fine chemicals.
Q6:How to contact us
You can choose your interested products and send inquiry to us.You can dial our telephone directly, you will get our reply.